PF3D7_1117300

Genome location: Pf3D7_11_v3:661,949..662,633(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.41	0.79
Trophozoite	possibly expressed	0.28	0.82
Schizont	possibly expressed	0.41	0.74
Gametocyte	not expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1117300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.204 | MFS: -3.323 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIJ4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215354

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	2	13
disruptive	1	3	1	21
missense	1	3	1	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	17	4	7
disruptive	2	14	12	44
missense	2	10	10	28

PlasmoDB Total SNPs: 31

Non-coding: 23 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 128 | Molecular Weight (kDa): 15.262

UniProt ID(s): Q8IIJ4

PDB ID(s): None

Isoelectric Point: 10.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A