PF3D7_1117400

Genome location: Pf3D7_11_v3:663,535..665,778(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.06	0.97
Schizont	expressed	1.29	0.39
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1117400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.944 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIJ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532460

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	16	18	25
disruptive	11	53	39	93
missense	8	45	34	81

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	42	19	35
disruptive	30	116	72	145
missense	16	94	57	94

PlasmoDB Total SNPs: 110

Non-coding: 81 | Synonymous: 17 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 397 | Molecular Weight (kDa): 44.596

UniProt ID(s): Q8IIJ3

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A