Product Description: peptidyl-tRNA hydrolase ICT1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.1.29 (Aminoacyl-tRNA hydrolase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004045 | aminoacyl-tRNA hydrolase activity |
| Function | GO:0043022 | ribosome binding |
| Process | GO:0070126 | mitochondrial translational termination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | nd | nd |
| Trophozoite | not expressed | nd | nd |
| Schizont | not expressed | nd | nd |
| Gametocyte | not expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1117600.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.189 | MFS: 0.277 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0930400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0930400)
Modification: Disrupted | RMgm-2626
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIJ1
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.1.29 | aminoacyl-tRNA hydrolase | EDTAtRNAtRNALystRNAfMettRNA-lysine5-azacytidine70 S ribosomeUncharged tRNAdeacetylated tRNAdiethyldicarbonatenon-esterified tRNALystRNA-formyl-methionine... |
| 3.1.1.29 | aminoacyl-tRNA hydrolase | EDTAtRNAtRNALystRNAfMettRNA-lysine5-azacytidine70 S ribosomeUncharged tRNAdeacetylated tRNAdiethyldicarbonatenon-esterified tRNALystRNA-formyl-methionine... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102939
Most Similar Human Ortholog: Q14197
TM-align score: 0.61 | RMSD: 2.32
Seq Identity: 0.32 | Length: 104 / 153
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000167862 | mitochondrial ribosomal protein L58 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 2 | 3 | 11 |
| disruptive | 1 | 7 | 3 | 22 |
| missense | 1 | 7 | 3 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 6 | 12 |
| disruptive | 1 | 20 | 10 | 37 |
| missense | 1 | 18 | 8 | 30 |
PlasmoDB Total SNPs: 108
Non-coding: 97 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 153 | Molecular Weight (kDa): 18.141
UniProt ID(s): Q8IIJ1
PDB ID(s): None
Isoelectric Point: 10.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000352 | Peptide chain release factor class I |
| PFam | PF00472 | Peptide chain release factor class I |
| Superfamily | SSF110916 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34454598 | Rational engineering of Saccharomyces cerevisiae towards improved tolerance tomultiple inhibitors in lignocellulose fermentations | Brandt BA, Garcia-Aparicio MDP, Gorgens JF, van Zyl WH | 10.1186/s13068-021-02021-w |
| 33686140 | A stalled-ribosome rescue factor Pth3 is required for mitochondrial translationagainst antibiotics in Saccharomyces cerevisiae | Hoshino S, Kanemura R, ..., Nameki N | 10.1038/s42003-021-01835-6 |