PF3D7_1118100 (AP1S)

Genome location: Pf3D7_11_v3:686,272..688,530(+)

Genome classification: Core

Function and Localization

Product Description: AP-1 complex subunit sigma, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030121	AP-1 adaptor complex
Component	GO:0030131	clathrin adaptor complex
Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.02	0.98
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1118100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.153 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0930000)

Relative Growth Rate: 0.10 ± 0.29
Confidence: 3.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8III7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q9Y587	AP-4 complex subunit sigma-1	Homo sapiens	OrthoDB	PRUCALOPRIDESR 147778US11649248, Example 1US11649248, Example 2...
Q3ZBB6	AP-4 complex subunit sigma-1	Bos taurus	OrthoDB	NSC_11603174

Orthology Information

Ortholog Group (OrthoMCL): OG6_100926

Most Similar Human Ortholog: A0A5F9ZI43

TM-align score: 0.99 | RMSD: 0.53

Seq Identity: 0.61 | Length: 147 / 155

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000106367	adaptor related protein complex 1 subunit sigma 1
ENSG00000152056	adaptor related protein complex 1 subunit sigma 3
ENSG00000182287	adaptor related protein complex 1 subunit sigma 2

Protein Information

Protein Length: 155 | Molecular Weight (kDa): 18.234

UniProt ID(s): Q8III7

PDB ID(s): None

Isoelectric Point: 9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011012	Longin-like domain superfamily
InterPro	IPR016635	Adaptor protein complex, sigma subunit
InterPro	IPR022775	AP complex, mu/sigma subunit
PFam	PF01217	AP complex, mu/sigma subunit
Superfamily	SSF64356	Longin-like domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 89

Non-coding: 86 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0