Product Description: heat shock protein 90, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0019901 | protein kinase binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.39 | 0.82 |
| Trophozoite | expressed | 0.94 | 0.53 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.75 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1118200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.151 | MFS: -2.791 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8III6
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.34) with 7EXP (Global RMSD=2.40)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q12931 | Heat shock protein 75 kDa, mitochondrial | Homo sapiens | HOGENOM, OMA, OrthoDB | CHEMBL3235333CHEMBL3235334CHEMBL3235335CHEMBL3235336... |
Ortholog Group (OrthoMCL): OG6_103348
Most Similar Human Ortholog: I3L239
TM-align score: 0.93 | RMSD: 1.49
Seq Identity: 0.41 | Length: 212 / 930
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126602 | TNF receptor associated protein 1 |
Protein Length: 930 | Molecular Weight (kDa): 108.465
UniProt ID(s): Q8III6
PDB ID(s): None
Isoelectric Point: 6.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001404 | Heat shock protein Hsp90 family |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| InterPro | IPR020575 | Heat shock protein Hsp90, N-terminal |
| InterPro | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| InterPro | IPR037196 | HSP90, C-terminal domain |
| PFam | PF00183 | Heat shock protein Hsp90 family |
| Superfamily | SSF110942 | HSP90, C-terminal domain |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF55874 | Histidine kinase/HSP90-like ATPase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 34 | 31 | 61 |
| disruptive | 26 | 62 | 40 | 95 |
| missense | 23 | 58 | 37 | 83 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 78 | 36 | 65 |
| disruptive | 43 | 138 | 76 | 169 |
| missense | 34 | 108 | 65 | 123 |
PlasmoDB Total SNPs: 251
Non-coding: 135 | Synonymous: 56 | Nonsynonymous: 59 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |