Product Description: histone acetyltransferase MYST
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.48 (Histone acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0044538 | host cell periphery |
| Component | GO:0005634 | nucleus |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0004402 | histone acetyltransferase activity |
| Function | GO:0042393 | histone binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003712 | transcription coregulator activity |
| Process | GO:0043983 | histone H4-K12 acetylation |
| Process | GO:0043984 | histone H4-K16 acetylation |
| Process | GO:0043981 | histone H4-K5 acetylation |
| Process | GO:0043982 | histone H4-K8 acetylation |
| Process | GO:0045892 | negative regulation of transcription, DNA-templated |
| Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.38 | 0.80 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | possibly expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1118600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.313 | MFS: -2.619 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0929500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8III2
"Best" AlphaFill ligand hit: SCA (succinyl-coenzyme a, Local RMSD=0.51) with 7D0S (Global RMSD=0.96)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.48 | histone acetyltransferase | CoADNARNABF1EDTAMB-3LTK14PU139A-485TTK21CPTH2CPTH6... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O95251 | Histone acetyltransferase KAT7 | OrthoDB | US11492346, Example 1US11492346, Example 2US11492346, Example 3US11492346, Example 4... | |
| Q92993 | Histone acetyltransferase KAT5 | Homo sapiens | OrthoDB | US11492346, Example 1US11492346, Example 3US11492346, Example 4US11492346, Example 5... |
| Q8WYB5 | Histone acetyltransferase KAT6B | OrthoDB | WO2022081807, Example 1WO2022081807, Example 2WO2022081807, Example 26WO2022081807, Example 79... | |
| Q92794 | Histone acetyltransferase KAT6A [507-778] | OrthoDB | CHEMBL4582784CHEMBL4562274CHEMBL4473757CHEMBL4520147... | |
| Q9H7Z6 | Histone acetyltransferase KAT8 | Homo sapiens | OrthoDB | US11492346, Example 1US11492346, Example 5US11492346, Example 6US11492346, Example 7... |
Ortholog Group (OrthoMCL): OG6_100632
Most Similar Human Ortholog: E9PJI1
TM-align score: 0.90 | RMSD: 2.12
Seq Identity: 0.46 | Length: 291 / 608
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103510 | lysine acetyltransferase 8 |
| ENSG00000172977 | lysine acetyltransferase 5 |
Protein Length: 608 | Molecular Weight (kDa): 71.134
UniProt ID(s): Q8III2
PDB ID(s): None
Isoelectric Point: 6.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002717 | Histone acetyltransferase domain, MYST-type |
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| InterPro | IPR016197 | Chromo-like domain superfamily |
| InterPro | IPR025995 | RNA binding activity-knot of a chromodomain |
| InterPro | IPR037995 | Histone acetyltransferase Esa1/KAT5/Tip60 |
| InterPro | IPR040706 | MYST, zinc finger domain |
| PFam | PF01853 | Histone acetyltransferase domain, MYST-type |
| PFam | PF11717 | RNA binding activity-knot of a chromodomain |
| PFam | PF17772 | MYST, zinc finger domain |
| Superfamily | SSF54160 | Chromo-like domain superfamily |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 27 | 24 | 54 |
| disruptive | 16 | 31 | 28 | 72 |
| missense | 8 | 23 | 19 | 57 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 84 | 38 | 40 |
| disruptive | 22 | 121 | 46 | 156 |
| missense | 10 | 76 | 39 | 102 |
PlasmoDB Total SNPs: 161
Non-coding: 114 | Synonymous: 18 | Nonsynonymous: 29 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20807207 | The MYST family histone acetyltransferase regulates gene expression and cellcycle in malaria parasite Plasmodium falciparum. | Miao J, Fan Q, ..., Cui L | 10.1111/j.1365-2958.2010.07371.x |
| 30026605 | Plasmodium falciparum RUVBL3 protein: a novel DNA modifying enzyme and aninteracting partner of essential HAT protein MYST. | Sen U, Saxena H, ..., Gupta A | 10.1038/s41598-018-29137-8 |
| 33046499 | Inhibition of Pf MYST Histone Acetyltransferase Activity Blocks Plasmodiumfalciparum Growth and Survival | Sen U, Nayak A, ..., Gupta A | 10.1128/AAC.00953-20 |