About Gene List

PF3D7_1118700 (MLC-B)

Genome location: Pf3D7_11_v3:707,860..713,551(-)

Genome classification: Core

Function and Localization

Product Description: myosin light chain B

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0016459 myosin complex
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.06 0.97
Schizont expressed 1.51 0.40
Gametocyte expressed 0.59 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1118700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.337 | MFS: -2.562 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0929400)

  • Relative Growth Rate: 0.24 ± 0.11
  • Confidence: 5.78

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0929400)

Modification: Tagged | RMgm-4668

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8III1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533578

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 41 26 38
disruptive 4 62 44 109
missense 4 54 42 94

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 78 24 36
disruptive 16 163 80 157
missense 9 136 63 114

PlasmoDB Total SNPs: 375

Non-coding: 332 | Synonymous: 35 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 652 | Molecular Weight (kDa): 78.739

UniProt ID(s): Q8III1

PDB ID(s): None

Isoelectric Point: 6.89

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011992 EF-hand domain pair
PFam N/A N/A
Superfamily SSF47473 EF-hand domain pair

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
25802338 The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location inInvasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. Yusuf NA, Green JL, ..., Holder AA 10.1074/jbc.M115.637694
36273584 Analysis of Plasmodium falciparum myosin B ATPase activity and structure incomplex with the calmodulin-like domain of its light chain MLC-B Pires I, Hung YF, ..., Kursula I 10.1016/j.jbc.2022.102634