Product Description: actin-related protein 2/3 complex subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005885 | Arp2/3 protein complex |
| Function | GO:0051015 | actin filament binding |
| Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
| Process | GO:0007015 | actin filament organization |
| Process | GO:0045010 | actin nucleation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.15 | 0.92 |
| Schizont | expressed | 0.10 | 0.94 |
| Gametocyte | expressed | 1.03 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1118800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.87 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0929300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0929300)
Modification: Disrupted | RMgm-2616
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIH9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101628
Most Similar Human Ortholog: E9PF58
TM-align score: 0.85 | RMSD: 2.65
Seq Identity: 0.14 | Length: 270 / 391
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130429 | actin related protein 2/3 complex subunit 1B |
| ENSG00000241685 | actin related protein 2/3 complex subunit 1A |
| ENSG00000284292 | novel protein, ARPC1A and ARPC1B readthrough |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 32 | 13 | 29 |
| disruptive | 3 | 26 | 16 | 31 |
| missense | 3 | 26 | 16 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 52 | 24 | 23 |
| disruptive | 8 | 67 | 30 | 91 |
| missense | 5 | 58 | 26 | 61 |
PlasmoDB Total SNPs: 117
Non-coding: 110 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 391 | Molecular Weight (kDa): 45.611
UniProt ID(s): Q8IIH9
PDB ID(s): None
Isoelectric Point: 4.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR017383 | Actin-related protein 2/3 complex subunit 1 |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 11743205 | Systematic genetic analysis with ordered arrays of yeast deletion mutants | Tong AH, Evangelista M, ..., Boone C | 10.1126/science.1065810 |
| 10377407 | Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the invivo and structural roles of individual subunits | Winter DC, Choe EY, Li R | 10.1073/pnas.96.13.7288 |