PF3D7_1118900

Genome location: Pf3D7_11_v3:716,730..718,412(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNLFSPVIFPLLIFLLSYNGSYA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1118900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.182 | MFS: -2.829 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIH8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130924

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	8	19
disruptive	2	17	13	30
missense	2	16	13	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	11	18
disruptive	6	44	28	60
missense	5	36	26	43

PlasmoDB Total SNPs: 75

Non-coding: 70 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 248 | Molecular Weight (kDa): 28.851

UniProt ID(s): Q8IIH8

PDB ID(s): None

Isoelectric Point: 5.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A