About Gene List

PF3D7_1119000

Genome location: Pf3D7_11_v3:718,042..720,478(-)

Genome classification: Core

Function and Localization

Product Description: acyl-CoA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.14 0.93
Trophozoite expressed 1.04 0.47
Schizont expressed 0.50 0.72
Gametocyte expressed 0.53 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1119000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.654 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0929100)

  • Relative Growth Rate: 0.76 ± 0.10
  • Confidence: 6.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0929100)

Modification: Disrupted | RMgm-2615

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIH7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104190

Most Similar Human Ortholog: Q9BR61

TM-align score: 0.43 | RMSD: 4.51

Seq Identity: 0.24 | Length: 156 / 371

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000230124 acyl-CoA binding domain containing 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 16 7 37
disruptive 13 43 15 37
missense 6 38 13 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 32 23 36
disruptive 22 86 51 109
missense 15 54 34 71

PlasmoDB Total SNPs: 151

Non-coding: 99 | Synonymous: 41 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 371 | Molecular Weight (kDa): 42.992

UniProt ID(s): Q8IIH7

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR035984 Acyl-CoA binding protein superfamily
InterPro IPR036770 Ankyrin repeat-containing domain superfamily
PFam PF00887 Acyl-CoA-binding protein, ACBP
PFam PF12796 Ankyrin repeat-containing domain
Superfamily SSF47027 Acyl-CoA binding protein superfamily
Superfamily SSF48403 Ankyrin repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895