About Gene List

PF3D7_1119200

Genome location: Pf3D7_11_v3:722,046..723,551(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.56 0.73
Trophozoite expressed 0.31 0.82
Schizont expressed 0.06 0.97
Gametocyte expressed 0.87 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1119200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.967 | MFS: -2.035 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0928900)

  • Relative Growth Rate: 0.41 ± 0.07
  • Confidence: 6.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0928900)

Modification: Disrupted | RMgm-2613

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYQ2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108013

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 5 4 4
disruptive 7 17 3 25
missense 4 16 3 15

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 10 4 9
disruptive 16 49 14 53
missense 8 33 8 31

PlasmoDB Total SNPs: 112

Non-coding: 87 | Synonymous: 17 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 150 | Molecular Weight (kDa): 17.57

UniProt ID(s): A0A143ZYQ2

PDB ID(s): None

Isoelectric Point: 10.36

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013885 Protein of unknown function DUF1764, eukaryotic
PFam PF08576 Protein of unknown function DUF1764, eukaryotic
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108