Product Description: splicing factor U2AF small subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0089701 | U2AF complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0030628 | pre-mRNA 3'-splice site binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.74 |
| Trophozoite | expressed | 0.86 | 0.54 |
| Schizont | expressed | 0.33 | 0.78 |
| Gametocyte | expressed | 0.44 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1119300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: -1.955 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0928800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIH4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101418
Most Similar Human Ortholog: Q8WU68
TM-align score: 0.78 | RMSD: 2.63
Seq Identity: 0.48 | Length: 191 / 294
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000160201 | U2 small nuclear RNA auxiliary factor 1 |
| ENSG00000161265 | U2 small nuclear RNA auxiliary factor 1 like 4 |
| ENSG00000275895 | U2 small nuclear RNA auxiliary factor 1 like 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 6 | 25 |
| disruptive | 3 | 8 | 16 | 24 |
| missense | 3 | 6 | 16 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 38 | 10 | 24 |
| disruptive | 5 | 36 | 30 | 66 |
| missense | 3 | 29 | 24 | 50 |
PlasmoDB Total SNPs: 108
Non-coding: 96 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 294 | Molecular Weight (kDa): 35.309
UniProt ID(s): Q8IIH4
PDB ID(s): None
Isoelectric Point: 7.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR000571 | Zinc finger, CCCH-type |
| InterPro | IPR003954 | RNA recognition motif domain, eukaryote |
| InterPro | IPR009145 | U2 auxiliary factor small subunit |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF00642 | Zinc finger, CCCH-type |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |