PF3D7_1119500

Genome location: Pf3D7_11_v3:736,057..737,776(+)

Genome classification: Core

Function and Localization

Product Description: AP-4 complex subunit mu, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030119	AP-type membrane coat adaptor complex
Component	GO:0030131	clathrin adaptor complex
Component	GO:0031410	cytoplasmic vesicle
Component	GO:0043231	intracellular membrane-bounded organelle
Component	GO:0005802	trans-Golgi network
Process	GO:0090160	Golgi to lysosome transport
Process	GO:0006605	protein targeting
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.93
Trophozoite	possibly expressed	0.24	0.84
Schizont	possibly expressed	0.15	0.89
Gametocyte	not expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1119500

Resistome Missense Mutations: Y346C

Resistome Compounds with Missense Mutations: Bortezomib

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.175 | MFS: -2.88 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0928600)

Relative Growth Rate: 0.07 ± 0.32
Confidence: 3.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIH2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105379

Most Similar Human Ortholog: C9JC87

TM-align score: 0.91 | RMSD: 2.27

Seq Identity: 0.31 | Length: 424 / 436

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000221838	adaptor related protein complex 4 subunit mu 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	21	11	24
disruptive	2	12	6	27
missense	2	11	6	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	43	15	39
disruptive	6	30	33	82
missense	5	23	25	56

PlasmoDB Total SNPs: 123

Non-coding: 90 | Synonymous: 29 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 436 | Molecular Weight (kDa): 51.137

UniProt ID(s): Q8IIH2

PDB ID(s): None

Isoelectric Point: 8.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001392	Clathrin adaptor, mu subunit
InterPro	IPR011012	Longin-like domain superfamily
InterPro	IPR022775	AP complex, mu/sigma subunit
InterPro	IPR028565	Mu homology domain
InterPro	IPR036168	AP-2 complex subunit mu, C-terminal superfamily
PFam	PF00928	Mu homology domain
PFam	PF01217	AP complex, mu/sigma subunit
Superfamily	SSF49447	AP-2 complex subunit mu, C-terminal superfamily
Superfamily	SSF64356	Longin-like domain superfamily