Product Description: ATP-dependent zinc metalloprotease FTSH, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.4.24.- (Metalloendopeptidases.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0042407 | cristae formation |
| Process | GO:0008053 | mitochondrial fusion |
| Process | GO:0034982 | mitochondrial protein processing |
| Process | GO:0065003 | protein-containing complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.43 | 0.74 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | possibly expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1119600
Resistome Missense Mutations: D665Y
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.141 | MFS: -2.915 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0928500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIH1
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.03) with 4KOD (Global RMSD=3.04)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.24.- | Ex: meprin A | GSHSDSATPADPNEMDTTPTXTNFEDTAEGTAPMSFPCMB... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100384
Most Similar Human Ortholog: Q9Y4W6
TM-align score: 0.64 | RMSD: 5.23
Seq Identity: 0.47 | Length: 600 / 1052
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000141385 | AFG3 like matrix AAA peptidase subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 48 | 35 | 61 |
| disruptive | 37 | 81 | 56 | 101 |
| missense | 27 | 67 | 50 | 90 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 106 | 51 | 53 |
| disruptive | 55 | 170 | 86 | 176 |
| missense | 35 | 142 | 68 | 134 |
PlasmoDB Total SNPs: 139
Non-coding: 91 | Synonymous: 21 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 1052 | Molecular Weight (kDa): 120.69
UniProt ID(s): Q8IIH1
PDB ID(s): None
Isoelectric Point: 9.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000642 | Peptidase M41 |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR003959 | ATPase, AAA-type, core |
| InterPro | IPR003960 | ATPase, AAA-type, conserved site |
| InterPro | IPR005936 | Peptidase, FtsH |
| InterPro | IPR011546 | Peptidase M41, FtsH extracellular |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR037219 | Peptidase M41-like |
| InterPro | IPR041569 | AAA ATPase, AAA+ lid domain |
| PFam | PF00004 | ATPase, AAA-type, core |
| PFam | PF01434 | Peptidase M41 |
| PFam | PF06480 | Peptidase M41, FtsH extracellular |
| PFam | PF17862 | AAA ATPase, AAA+ lid domain |
| Superfamily | SSF140990 | Peptidase M41-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |