PF3D7_1119700

Genome location: Pf3D7_11_v3:743,663..746,472(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	possibly expressed	0.02	0.98
Schizont	possibly expressed	0.17	0.89
Gametocyte	expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1119700

Resistome Missense Mutations: S168C

Resistome Compounds with Missense Mutations: OSM-S-106

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 4 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.788 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0928400)

Modification: Disrupted | RMgm-2609

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIH0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532432

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	21	8	16
disruptive	11	31	19	55
missense	7	19	16	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	27	19	26
disruptive	22	73	44	105
missense	9	57	34	59

PlasmoDB Total SNPs: 226

Non-coding: 202 | Synonymous: 20 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 352 | Molecular Weight (kDa): 41.773

UniProt ID(s): Q8IIH0

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001289	Nuclear transcription factor Y subunit A
PFam	PF02045	Nuclear transcription factor Y subunit A
Superfamily	N/A	N/A