About Gene List

PF3D7_1119900 (SEC16)

Genome location: Pf3D7_11_v3:748,255..755,195(+)

Genome classification: Core

Function and Localization

Product Description: protein transport protein SEC16, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.95 0.58
Trophozoite expressed 0.64 0.64
Schizont expressed 0.55 0.67
Gametocyte expressed 0.48 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1119900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.099 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIG8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532728

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 71 40 88
disruptive 99 283 156 376
missense 57 222 138 304

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 146 65 108
disruptive 166 623 242 534
missense 89 489 186 357

PlasmoDB Total SNPs: 366

Non-coding: 144 | Synonymous: 88 | Nonsynonymous: 134 | Stop Codon: 0

Protein Information

Protein Length: 1749 | Molecular Weight (kDa): 208.589

UniProt ID(s): Q8IIG8

PDB ID(s): None

Isoelectric Point: 5.91

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024298 Ancestral coatomer element 1, Sec16/Sec31
PFam PF12931 Ancestral coatomer element 1, Sec16/Sec31
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31851588 Sec16 function in ER export and autophagy is independent of its phosphorylationin Saccharomyces cerevisiae Yorimitsu T, Sato K 10.1091/mbc.E19-08-0477
29532188 Balanced trafficking between the ER and the Golgi apparatus increases proteinsecretion in yeast Bao J, Huang M, Petranovic D, Nielsen J 10.1186/s13568-018-0571-x