About Gene List

PF3D7_1120000

Genome location: Pf3D7_11_v3:755,951..760,604(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0016020 membrane
Component GO:0005634 nucleus
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.48 0.39
Trophozoite expressed 1.34 0.36
Schizont expressed 0.31 0.83
Gametocyte expressed 1.01 0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1120000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.155 | MFS: -2.903 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0928200)

  • Relative Growth Rate: 0.25 ± 0.14
  • Confidence: 5.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0928200)

Modification: Disrupted | RMgm-2608

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIG7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119861

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 27 14 35
disruptive 24 93 48 83
missense 16 60 36 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 50 26 39
disruptive 54 172 70 140
missense 27 110 43 89

PlasmoDB Total SNPs: 605

Non-coding: 165 | Synonymous: 276 | Nonsynonymous: 164 | Stop Codon: 0

Protein Information

Protein Length: 1070 | Molecular Weight (kDa): 128.952

UniProt ID(s): A0A143ZYR6, Q8IIG7

PDB ID(s): None

Isoelectric Point: 5.14

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF58113 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596