Product Description: phosphoglycerate mutase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.4.2.11 (Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0004619 | phosphoglycerate mutase activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006096 | glycolytic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.60 |
| Trophozoite | expressed | 1.71 | 0.27 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.57 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1120100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.154 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0928100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIG6
"Best" AlphaFill ligand hit: PGA (2-phosphoglycolic acid, Local RMSD=0.08) with 7N3S (Global RMSD=1.65)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) | MJE3vanadatePGMI-004AgemcitabinemetavanadatetetrathionateAlizarin Red S2,3-ButanedionediethyldicarbonateSodium metavanadatebenzene hexacarboxylateepigallocatechin gallate... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P07738 | Bisphosphoglycerate mutase | HOGENOM, OrthoDB, OrthoMCL BLAST | US20230348450, Example 1US20230348450, Example 2US20230348450, Example 3US20230348450, Example 4... | |
| P18669 | Phosphoglycerate mutase 1 | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | CHEMBL3335789CHEMBL4793513CHEMBL4742013CHEMBL4763924... |
Ortholog Group (OrthoMCL): OG6_101500
Most Similar Human Ortholog: P15259
TM-align score: 0.98 | RMSD: 1.02
Seq Identity: 0.57 | Length: 250 / 250
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164708 | phosphoglycerate mutase 2 |
| ENSG00000171314 | phosphoglycerate mutase 1 |
Protein Length: 250 | Molecular Weight (kDa): 28.77
UniProt ID(s): Q8IIG6
Isoelectric Point: 8.41
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001345 | Phosphoglycerate/bisphosphoglycerate mutase, active site |
| InterPro | IPR005952 | Phosphoglycerate mutase 1 |
| InterPro | IPR013078 | Histidine phosphatase superfamily, clade-1 |
| InterPro | IPR029033 | Histidine phosphatase superfamily |
| PFam | PF00300 | Histidine phosphatase superfamily, clade-1 |
| Superfamily | SSF53254 | Histidine phosphatase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 131
Non-coding: 123 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 32310999 | Insights into the intracellular localization, protein associations andartemisinin resistance properties of Plasmodium falciparum K13. | Gnadig NF, Stokes BH, ..., Fidock DA | 10.1371/journal.ppat.1008482 |