Product Description: CorA-like Mg2+ transporter protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0015095 | magnesium ion transmembrane transporter activity |
| Process | GO:0015693 | magnesium ion transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | possibly expressed | 0.34 | 0.79 |
| Schizont | not expressed | 0.18 | 0.87 |
| Gametocyte | not expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1120300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.316 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1017000)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0929900)
Modification: Disrupted | RMgm-4782
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIG4
"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.87) with 5T3U (Global RMSD=22.47)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102708
Most Similar Human Ortholog: Q9HD23
TM-align score: 0.64 | RMSD: 3.51
Seq Identity: 0.17 | Length: 325 / 529
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124532 | magnesium transporter MRS2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 19 | 5 | 27 |
| disruptive | 5 | 43 | 18 | 46 |
| missense | 5 | 42 | 17 | 43 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 36 | 18 | 28 |
| disruptive | 16 | 85 | 51 | 106 |
| missense | 12 | 69 | 40 | 59 |
PlasmoDB Total SNPs: 91
Non-coding: 65 | Synonymous: 16 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 529 | Molecular Weight (kDa): 63.252
UniProt ID(s): A0A143ZZ84, Q8IIG4
PDB ID(s): None
Isoelectric Point: 8.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR039204 | Magnesium transporter MRS2-like |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35517506 | Regulation of Peroxisome Homeostasis by Post-Translational Modification in theMethylotrophic Yeast Komagataella phaffii | Ohsawa S, Oku M, Yurimoto H, Sakai Y | 10.3389/fcell.2022.887806 |
| 30110338 | The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2'srole in heterochromatin assembly in fission yeast | Maksimov V, Oya E, ..., Nakayama JI | 10.1371/journal.pone.0201101 |