PF3D7_1120400

Genome location: Pf3D7_11_v3:768,725..771,841(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase fold domain containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.26	0.86
Trophozoite	expressed	0.07	0.95
Schizont	possibly expressed	0.03	0.98
Gametocyte	not expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1120400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.033 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225600)

Relative Growth Rate: 1.03 ± 0.08
Confidence: 6.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIG3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100915

Most Similar Human Ortholog: Q5VST6

TM-align score: 0.88 | RMSD: 2.33

Seq Identity: 0.31 | Length: 278 / 382

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107362	abhydrolase domain containing 17B, depalmitoylase
ENSG00000129968	abhydrolase domain containing 17A, depalmitoylase
ENSG00000136379	abhydrolase domain containing 17C, depalmitoylase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	doubleton	singleton
synonymous	0	1
disruptive	1	0
missense	0	0

PlasmoDB Total SNPs: 151

Non-coding: 102 | Synonymous: 20 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 382 | Molecular Weight (kDa): 44.726

UniProt ID(s): Q8IIG3

PDB ID(s): None

Isoelectric Point: 7.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022742	Serine aminopeptidase, S33
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF12146	Serine aminopeptidase, S33
Superfamily	SSF53474	Alpha/Beta hydrolase fold