About Gene List

PF3D7_1120600

Genome location: Pf3D7_11_v3:775,233..783,909(-)

Genome classification: Core

Function and Localization

Product Description: DDRGK domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite possibly expressed 0.88 0.57
Schizont possibly expressed 0.20 0.89
Gametocyte expressed 1.21 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1120600

Resistome Missense Mutations: N473S

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.375 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0927700)

Modification: Disrupted | RMgm-2605

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIG1

"Best" AlphaFill ligand hit: FON (n-{[4-({[(6r)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-l-glutamic acid, Local RMSD=35.76) with 4LXQ (Global RMSD=52.24)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104252

Most Similar Human Ortholog: Q96HY6

TM-align score: 0.34 | RMSD: 3.26

Seq Identity: 0.21 | Length: 124 / 2545

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000198171 DDRGK domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 27 73 36 94
disruptive 147 392 193 435
missense 71 277 153 330

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 39 132 67 106
disruptive 254 650 271 509
missense 127 474 205 370

PlasmoDB Total SNPs: 601

Non-coding: 139 | Synonymous: 212 | Nonsynonymous: 248 | Stop Codon: 2

Protein Information

Protein Length: 2545 | Molecular Weight (kDa): 303.407

UniProt ID(s): A0A144A2K5, Q8IIG1

PDB ID(s): None

Isoelectric Point: 5.18

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019153 DDRGK domain containing protein
InterPro IPR036390 Winged helix DNA-binding domain superfamily
PFam N/A N/A
Superfamily SSF46785 Winged helix DNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094