About Gene List

PF3D7_1120700

Genome location: Pf3D7_11_v3:783,924..789,129(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.09 0.96
Trophozoite possibly expressed 0.40 0.76
Schizont possibly expressed 0.21 0.87
Gametocyte expressed 1.77 0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1120700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.812 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIG0

"Best" AlphaFill ligand hit: CDP (cytidine-5'-diphosphate, Local RMSD=0.63) with 5WCN (Global RMSD=18.64)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532640

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 49 20 59
disruptive 40 150 84 192
missense 20 115 75 160

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 83 39 75
disruptive 77 348 160 310
missense 40 243 126 205

PlasmoDB Total SNPs: 224

Non-coding: 92 | Synonymous: 71 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 1252 | Molecular Weight (kDa): 149.756

UniProt ID(s): Q8IIG0

PDB ID(s): None

Isoelectric Point: 9.85

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097