About Gene List

PF3D7_1120900 (HSBP)

Genome location: Pf3D7_11_v3:790,267..791,082(+)

Genome classification: Core

Function and Localization

Product Description: heat shock factor-binding protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005829 cytosol
Component GO:0005634 nucleus
Function GO:0005515 protein binding
Process GO:0070370 cellular heat acclimation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.01 1.00
Trophozoite expressed 0.07 0.95
Schizont expressed 0.01 0.99
Gametocyte not expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1120900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.497 | MFS: -3.491 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIF8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103734

Most Similar Human Ortholog: O75506

TM-align score: 0.69 | RMSD: 1.67

Seq Identity: 0.26 | Length: 61 / 113

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000230989 heat shock factor binding protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 26

Non-coding: 13 | Synonymous: 11 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 113 | Molecular Weight (kDa): 13.17

UniProt ID(s): Q8IIF8

PDB ID(s): None

Isoelectric Point: 4.37

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009643 Heat shock factor binding 1
PFam PF06825 Heat shock factor binding 1
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
24674379 Identification of heat shock factor binding protein in Plasmodium falciparum. Sayeed SK, Shah V, ..., Tatu US 10.1186/1475-2875-13-118
37275960 Targeting heparan sulfate-protein interactions with oligosaccharides andmonoclonal antibodies Li M, Pedersen LC, Xu D 10.3389/fmolb.2023.1194293