About Gene List

PF3D7_1121100

Genome location: Pf3D7_11_v3:793,500..800,524(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.00 0.56
Trophozoite not expressed 0.83 0.56
Schizont not expressed 1.11 0.46
Gametocyte not expressed 0.74 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1121100

Resistome Missense Mutations: D633Y

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.69 | MFS: -2.246 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0927200)

  • Relative Growth Rate: 0.06 ± 0.07
  • Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIF6

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=3.63) with 2VL8 (Global RMSD=36.25)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119987

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 50 29 73
disruptive 31 116 72 171
missense 22 102 60 151

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 91 49 81
disruptive 68 240 124 249
missense 47 197 106 198

PlasmoDB Total SNPs: 277

Non-coding: 186 | Synonymous: 49 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 1544 | Molecular Weight (kDa): 184.917

UniProt ID(s): Q8IIF6

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104