PF3D7_1121200

Genome location: Pf3D7_11_v3:800,552..801,465(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.06	0.96
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1121200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.121 | MFS: -3.041 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0927200)

Relative Growth Rate: 0.06 ± 0.07
Confidence: 6.69

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0927100)

Modification: Tagged | RMgm-4974

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIF5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119987

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	4	3
disruptive	0	6	4	23
missense	0	5	4	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	12	2	8
disruptive	3	25	16	41
missense	3	13	11	22

PlasmoDB Total SNPs: 36

Non-coding: 23 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 155 | Molecular Weight (kDa): 19.148

UniProt ID(s): Q8IIF5

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21