Product Description: tyrosine kinase-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.10.2 (Non-specific protein-tyrosine kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044164 | host cell cytosol |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | not expressed | 0.67 | 0.68 |
| Schizont | possibly expressed | 0.85 | 0.61 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1121300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.436 | #Insertions: 8
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0927000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0927000)
Modification: Disrupted | RMgm-2602
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIF4
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.27) with 5LPZ (Global RMSD=1.80)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.10.2 | non-specific protein-tyrosine kinase | ADPPP1PP2T47ChkCskPIP2CMP6RNAiWASPmorinAG490... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_121491
Most Similar Human Ortholog: Q9Y616
TM-align score: 0.55 | RMSD: 5.29
Seq Identity: 0.24 | Length: 400 / 1675
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000090376 | interleukin 1 receptor associated kinase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 59 | 21 | 75 |
| disruptive | 21 | 94 | 60 | 210 |
| missense | 16 | 80 | 49 | 175 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 102 | 58 | 87 |
| disruptive | 53 | 235 | 155 | 290 |
| missense | 29 | 186 | 127 | 205 |
PlasmoDB Total SNPs: 214
Non-coding: 91 | Synonymous: 92 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 1675 | Molecular Weight (kDa): 200.426
UniProt ID(s): Q8IIF4
PDB ID(s): None
Isoelectric Point: 7.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| InterPro | IPR008271 | Serine/threonine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF07714 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24045796 | A secreted Plasmodium falciparum kinase reveals a signature motif forclassification of tyrosine kinase-like kinases. | Abdi AI, Carvalho TG, Wilkes JM, Doerig C | 10.1099/mic.0.070409-0 |
| 9000376 | Analysis of a transketolase gene from Kluyveromyces lactis reveals that the yeastenzymes are more related to transketolases of prokaryotic origins than to thoseof higher eukaryotes | Jacoby JJ, Heinisch JJ | 10.1007/s002940050171 |
| 25394484 | Cloning of the transketolase gene from erythritol-producing yeast Candidamagnoliae | Yoo BH, Park EH, Seo JH, Kim MD | 10.4014/jmb.1407.07032 |
| 22579386 | Characterization of non-oxidative transaldolase and transketolase enzymes in thepentose phosphate pathway with regard to xylose utilization by recombinantSaccharomyces cerevisiae | Matsushika A, Goshima T, ..., Yano S | 10.1016/j.enzmictec.2012.03.008 |
| 9495741 | Msn2p and Msn4p control a large number of genes induced at the diauxic transitionwhich are repressed by cyclic AMP in Saccharomyces cerevisiae | Boy-Marcotte E, Perrot M, ..., Jacquet M | 10.1128/JB.180.5.1044-1052.1998 |
| 30252062 | Reassessment of requirements for anaerobic xylose fermentation by engineered,non-evolved Saccharomyces cerevisiae strains | Bracher JM, Martinez-Rodriguez OA, ..., Pronk JT | 10.1093/femsyr/foy104 |
| 28869192 | Selection of yeast Saccharomyces cerevisiae promoters available for xylosecultivation and fermentation | Nambu-Nishida Y, Sakihama Y, ..., Kondo A | 10.1016/j.jbiosc.2017.08.001 |
| 20816840 | Metabolome, transcriptome and metabolic flux analysis of arabinose fermentationby engineered Saccharomyces cerevisiae | Wisselink HW, Cipollina C, ..., van Maris AJ | 10.1016/j.ymben.2010.08.003 |
| 8641413 | Mapping of DNA-binding proteins along the yeast genome by UV-induced DNA-proteincrosslinking | Papatsenko DA, Priporova IV, Belikov SV, Karpov VL | 10.1016/0014-5793(96)00091-9 |
| 7916691 | TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequenceand deletion analysis of the gene | Schaaff-Gerstenschlager I, Mannhaupt G, ..., Feldmann H | 10.1111/j.1432-1033.1993.tb18268.x |
| 29621349 | Signature pathway expression of xylose utilization in the genetically engineeredindustrial yeast Saccharomyces cerevisiae | Feng Q, Liu ZL, Weber SA, Li S | 10.1371/journal.pone.0195633 |