PF3D7_1121400

Genome location: Pf3D7_11_v3:810,210..812,290(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.25	0.88
Trophozoite	not expressed	0.22	0.87
Schizont	possibly expressed	0.25	0.85
Gametocyte	not expressed	0.40	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1121400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.087 | #Insertions: 6

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0926900)

Relative Growth Rate: 0.82 ± 0.16
Confidence: 5.04

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0926900)

Modification: Disrupted | RMgm-4236

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIF2

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.41) with 4GM8 (Global RMSD=2.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111964

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	8	29
disruptive	1	30	21	59
missense	1	30	21	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	31	13	28
disruptive	7	74	49	101
missense	5	63	43	76

PlasmoDB Total SNPs: 60

Non-coding: 31 | Synonymous: 25 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 582 | Molecular Weight (kDa): 67.035

UniProt ID(s): Q8IIF2

PDB ID(s): None

Isoelectric Point: 8.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily