About Gene List

PF3D7_1121500

Genome location: Pf3D7_11_v3:812,583..814,130(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.16 0.91
Trophozoite not expressed 0.27 0.83
Schizont possibly expressed 0.19 0.87
Gametocyte not expressed 0.18 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1121500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.194 | MFS: -3.409 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0926800)

Modification: Other | RMgm-442

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIF1

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=1.16) with 7US5 (Global RMSD=18.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532547

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 21 11 19
disruptive 5 55 21 68
missense 5 51 21 61

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 29 20 16
disruptive 25 96 51 99
missense 18 76 44 70

PlasmoDB Total SNPs: 22

Non-coding: 0 | Synonymous: 14 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 515 | Molecular Weight (kDa): 62.23

UniProt ID(s): Q8IIF1

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21