Product Description: exported protein 1
SignalP Peptide: MKILSVFFLALFFIIFNKESLA
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020026 | merozoite dense granule |
| Component | GO:0005634 | nucleus |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0015267 | channel activity |
| Function | GO:0004364 | glutathione transferase activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006749 | glutathione metabolic process |
| Process | GO:0042493 | response to drug |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 3.67 | 0.01 |
| Trophozoite | expressed | 3.52 | 0.02 |
| Schizont | expressed | 1.28 | 0.40 |
| Gametocyte | expressed | 1.52 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1121600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.988 | MFS: -1.886 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0926700)
Modification: Mutated | RMgm-4655
More info: PhenoPlasm Link
AlphaFill Uniprot ID: P04923
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 155
Non-coding: 143 | Synonymous: 3 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 162 | Molecular Weight (kDa): 17.296
UniProt ID(s): P04923, P04926, Q25840, Q548U2, Q5VKK2, Q5WRH8, Q6V9G4, Q6V9G6, Q6V9G9, Q6V9H1, Q6V9H2, Q8IIF0, Q9U590
PDB ID(s): None
Isoelectric Point: 5.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | PF06589 | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12456681 | The signal sequence of exported protein-1 directs the green fluorescent proteinto the parasitophorous vacuole of transfected malaria parasites. | Adisa A, Rug M, ..., Tilley L | 10.1074/jbc.M207039200 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23361006 | Spatial association with PTEX complexes defines regions for effector export intoPlasmodium falciparum-infected erythrocytes. | Riglar DT, Rogers KL, ..., Cowman AF | 10.1038/ncomms2449 |
| 25126794 | Supergenomic network compression and the discovery of EXP1 as a glutathionetransferase inhibited by artesunate. | Lisewski AM, Quiros JP, ..., Lichtarge O | 10.1016/j.cell.2014.07.011 |
| 27892646 | Trafficking of Pf Exp1 to the parasitophorous vacuolar membrane of Plasmodiumfalciparum is independent of protein folding and the P TEX translocon | Tribensky A, Graf AW, ..., Przyborski JM | 10.1111/cmi.12710 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29324251 | Potential role of Plasmodium falciparum exported protein 1 in the chloroquinemode of action. | Lisewski AM, Quiros JP, ..., Lichtarge O | 10.1016/j.ijpddr.2017.12.003 |
| 29886341 | Plasmodium falciparum Exported Protein 1 is localized to dense granules inmerozoites. | Iriko H, Ishino T, ..., Tsuboi T | 10.1016/j.parint.2018.06.001 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31568532 | EXP1 is critical for nutrient uptake across the parasitophorous vacuole membraneof malaria parasites. | Mesen-Ramirez P, Bergmann B, ..., Spielmann T | 10.1371/journal.pbio.3000473 |
| 34863371 | The parasitophorous vacuole nutrient channel is critical for drug access inmalaria parasites and modulates the artemisinin resistance fitness cost. | Mesen-Ramirez P, Bergmann B, ..., Spielmann T | 10.1016/j.chom.2021.11.002 |