Product Description: GPI transamidase component GPI16, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0042765 | GPI-anchor transamidase complex |
| Function | GO:0003923 | GPI-anchor transamidase activity |
| Process | GO:0016255 | attachment of GPI anchor to protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.31 | 0.80 |
| Schizont | possibly expressed | 0.13 | 0.92 |
| Gametocyte | not expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1122100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -3.131 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0926200)
Modification: Disrupted | RMgm-4459
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIE5
"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.21) with 8P20 (Global RMSD=20.15)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103068
Most Similar Human Ortholog: Q969N2
TM-align score: 0.70 | RMSD: 4.25
Seq Identity: 0.15 | Length: 439 / 514
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124155 | phosphatidylinositol glycan anchor biosynthesis class T |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 20 | 9 | 19 |
| disruptive | 2 | 31 | 15 | 48 |
| missense | 2 | 31 | 14 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 28 | 19 | 26 |
| disruptive | 9 | 65 | 31 | 95 |
| missense | 4 | 58 | 28 | 62 |
PlasmoDB Total SNPs: 61
Non-coding: 42 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 2
Protein Length: 514 | Molecular Weight (kDa): 60.78
UniProt ID(s): Q8IIE5
PDB ID(s): None
Isoelectric Point: 6.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007245 | GPI transamidase component PIG-T |
| PFam | PF04113 | GPI transamidase component PIG-T |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29784863 | The Glycosylphosphatidylinositol Transamidase Complex Subunit Pb GPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria | Liu Q, Zhao Y, ..., Cao Y | 10.1128/IAI.00929-17 |
| 11598210 | The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p,and Gpi16p | Fraering P, Imhof I, ..., Conzelmann A | 10.1091/mbc.12.10.3295 |