Product Description: JmjC domain-containing protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.14.11.- (With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.);1.14.11.27 ([Histone H3]-dimethyl-L-lysine(36) demethylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
| Function | GO:0032452 | histone demethylase activity |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.86 | 0.61 |
| Trophozoite | not expressed | 0.40 | 0.78 |
| Schizont | not expressed | 0.52 | 0.73 |
| Gametocyte | not expressed | 1.15 | 0.42 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1122200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.57 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIE4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.14.11.- | Ex: gibberellin-44 dioxygenase | O2FMNSDSATPGTPEDTAIOX1NOFDPBITZnCl2AR692AR780... |
| 1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9NWT6 | Hypoxia-inducible factor 1-alpha inhibitor | OrthoDB | pyridine carboxylate, 6aCHEMBL5091848CHEMBL5072902 |
Protein Length: 446 | Molecular Weight (kDa): 53.801
UniProt ID(s): Q8IIE4
PDB ID(s): None
Isoelectric Point: 10.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR041667 | Cupin-like domain 8 |
| PFam | PF13621 | Cupin-like domain 8 |
| Superfamily | SSF51197 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 12 | 21 |
| disruptive | 4 | 37 | 19 | 50 |
| missense | 4 | 35 | 15 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 29 | 20 | 28 |
| disruptive | 12 | 84 | 49 | 68 |
| missense | 9 | 68 | 45 | 57 |
PlasmoDB Total SNPs: 131
Non-coding: 114 | Synonymous: 7 | Nonsynonymous: 10 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32272012 | Disruption of the Plasmodium falciparum Life Cycle through TranscriptionalReprogramming by Inhibitors of Jumonji Demethylases. | Matthews KA, Senagbe KM, ..., Martinez ED | 10.1021/acsinfecdis.9b00455 |