PF3D7_1122300

Genome location: Pf3D7_11_v3:846,929..848,014(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.64	0.70
Trophozoite	not expressed	0.18	0.89
Schizont	not expressed	0.36	0.77
Gametocyte	not expressed	0.55	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1122300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -0.447 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0926000)

Relative Growth Rate: 1.03 ± 0.17
Confidence: 4.94

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0926000)

Modification: Disrupted | RMgm-2600

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIE3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533460

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	8	16
disruptive	4	14	7	35
missense	4	14	7	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	31	8	23
disruptive	13	41	29	90
missense	8	24	24	58

PlasmoDB Total SNPs: 17

Non-coding: 0 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 361 | Molecular Weight (kDa): 42.609

UniProt ID(s): Q8IIE3

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094