PF3D7_1122400

Genome location: Pf3D7_11_v3:848,748..852,976(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.46	0.78
Trophozoite	expressed	0.59	0.66
Schizont	expressed	0.17	0.89
Gametocyte	expressed	0.56	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1122400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.071 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIE2

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=0.13) with 3IED (Global RMSD=16.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532421

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	28	17	36
disruptive	5	57	25	109
missense	5	53	23	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	45	28	54
disruptive	28	130	81	173
missense	17	107	66	129

PlasmoDB Total SNPs: 187

Non-coding: 150 | Synonymous: 27 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 851 | Molecular Weight (kDa): 101.938

UniProt ID(s): Q8IIE2

PDB ID(s): None

Isoelectric Point: 5.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A