About Gene List

PF3D7_1122500 (KIC10)

Genome location: Pf3D7_11_v3:852,985..859,371(+)

Genome classification: Core

Function and Localization

Product Description: protein KIC10

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.12 0.94
Trophozoite not expressed 0.75 0.60
Schizont not expressed 0.66 0.64
Gametocyte not expressed 0.60 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1122500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.929 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIE1

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.88) with 6JWQ (Global RMSD=41.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533349

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 45 39 77
disruptive 55 214 127 318
missense 23 171 111 271

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 116 55 97
disruptive 111 499 233 458
missense 46 406 204 329

PlasmoDB Total SNPs: 176

Non-coding: 41 | Synonymous: 85 | Nonsynonymous: 49 | Stop Codon: 1

Protein Information

Protein Length: 1956 | Molecular Weight (kDa): 231.013

UniProt ID(s): Q8IIE1

PDB ID(s): None

Isoelectric Point: 8.09

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108