PF3D7_1122600

Genome location: Pf3D7_11_v3:859,451..868,220(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.13	0.93
Schizont	not expressed	0.21	0.87
Gametocyte	not expressed	1.04	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1122600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.496 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIE0

"Best" AlphaFill ligand hit: TEW (6-tungstotellurate(vi), Local RMSD=0.12) with 6NYS (Global RMSD=17.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533034

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	67	40	96
disruptive	20	138	107	228
missense	20	133	104	213

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	150	62	105
disruptive	61	330	148	327
missense	41	282	124	264

PlasmoDB Total SNPs: 382

Non-coding: 299 | Synonymous: 57 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 1832 | Molecular Weight (kDa): 217.704

UniProt ID(s): Q8IIE0

PDB ID(s): None

Isoelectric Point: 7.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A