PF3D7_1122700

Genome location: Pf3D7_11_v3:868,275..869,789(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.12	0.92
Schizont	expressed	0.23	0.85
Gametocyte	expressed	0.06	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1122700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -3.326 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0925600)

Relative Growth Rate: 0.10 ± 0.05
Confidence: 7.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IID6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532701

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	6	16
disruptive	2	19	11	31
missense	2	19	11	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	21	10	14
disruptive	3	54	29	57
missense	3	44	26	46

PlasmoDB Total SNPs: 76

Non-coding: 57 | Synonymous: 12 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 254 | Molecular Weight (kDa): 30.542

UniProt ID(s): Q8IID6

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094