PF3D7_1123000

Genome location: Pf3D7_11_v3:895,885..906,868(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123000

Resistome Missense Mutations: D580N

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 5 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -2.752 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IID3

"Best" AlphaFill ligand hit: DTP (, Local RMSD=4.21) with 5OLK (Global RMSD=29.20)

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_532441

No human ortholog(s)

Protein Information

Protein Length: 2467 | Molecular Weight (kDa): 292.909

UniProt ID(s): Q8IID3, Q9GVB4

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 522

Non-coding: 185 | Synonymous: 216 | Nonsynonymous: 121 | Stop Codon: 0