PF3D7_1123200 (LRR11)

Genome location: Pf3D7_11_v3:917,394..921,163(+)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0019005	SCF ubiquitin ligase complex
Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Process	GO:0006511	ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.24	0.85
Schizont	possibly expressed	0.59	0.66
Gametocyte	not expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -3.192 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0925100)

Relative Growth Rate: 0.14 ± 0.06
Confidence: 7.18

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0925100)

Modification: Tagged | RMgm-5337

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IID1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101394

Most Similar Human Ortholog: Q8N1E6

TM-align score: 0.75 | RMSD: 3.62

Seq Identity: 0.21 | Length: 363 / 814

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171823	F-box and leucine rich repeat protein 14

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	25	27	44
disruptive	25	85	41	93
missense	17	60	32	78

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	70	33	58
disruptive	52	172	75	169
missense	31	125	61	112

PlasmoDB Total SNPs: 172

Non-coding: 125 | Synonymous: 29 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 814 | Molecular Weight (kDa): 93.334

UniProt ID(s): Q1L699, Q8IID1

PDB ID(s): None

Isoelectric Point: 9.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52047	N/A