PF3D7_1123300

Genome location: Pf3D7_11_v3:921,384..924,526(+)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.27	0.86
Trophozoite	possibly expressed	0.52	0.69
Schizont	expressed	0.50	0.68
Gametocyte	not expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.807 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0925000)

Relative Growth Rate: 1.12 ± 0.26
Confidence: 4.10

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0925000)

Modification: Disrupted | RMgm-2594

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IID0

"Best" AlphaFill ligand hit: CPQ (n,n-bis(3-d-gluconamidopropyl)deoxycholamide, Local RMSD=0.45) with 4AYC (Global RMSD=9.54)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q680I0	E3 ubiquitin-protein ligase ORTHRUS 5		OrthoMCL BLAST	US10543221, Formula 13US10543221, Formula 14US10543221, Formula 15

Orthology Information

Ortholog Group (OrthoMCL): OG6_533344

No human ortholog(s)

Protein Information

Protein Length: 689 | Molecular Weight (kDa): 79.734

UniProt ID(s): Q8IID0

PDB ID(s): None

Isoelectric Point: 5.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
PFam	PF13923	N/A
Superfamily	SSF57850	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	31	23	38
disruptive	19	82	48	100
missense	7	49	34	72

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	63	35	38
disruptive	51	195	105	171
missense	18	124	81	92

PlasmoDB Total SNPs: 174

Non-coding: 48 | Synonymous: 75 | Nonsynonymous: 51 | Stop Codon: 0

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104