About Gene List

PF3D7_1123500 (GP2)

Genome location: Pf3D7_11_v3:928,601..933,649(-)

Genome classification: Core

Function and Localization

Product Description: golgi protein 2

SignalP Peptide: MNIFKRYIFFLCSFYLLYVTCSS

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005794 Golgi apparatus
Component GO:0020011 apicoplast
Component GO:0020003 symbiont-containing vacuole
Function GO:0005515 protein binding
Function GO:0044877 protein-containing complex binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.00 0.55
Trophozoite expressed 0.93 0.51
Schizont expressed 0.79 0.58
Gametocyte possibly expressed 0.80 0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.283 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0924800)

Modification: Disrupted | RMgm-4439

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIC8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532891

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 22 50 30 63
disruptive 55 123 80 197
missense 21 86 65 149

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 32 111 41 70
disruptive 80 361 155 384
missense 33 241 121 244

PlasmoDB Total SNPs: 272

Non-coding: 111 | Synonymous: 95 | Nonsynonymous: 66 | Stop Codon: 0

Protein Information

Protein Length: 1336 | Molecular Weight (kDa): 153.698

UniProt ID(s): Q8IIC8

PDB ID(s): None

Isoelectric Point: 7.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28784333 Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. Khosh-Naucke M, Becker J, ..., Spielmann T 10.1016/j.ijmm.2017.07.007
29579782 Identification of a Golgi apparatus protein complex important for the asexualerythrocytic cycle of the malaria parasite Plasmodium falciparum. Hallee S, Theriault C, ..., Richard D 10.1111/cmi.12843
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895