PF3D7_1123600

Genome location: Pf3D7_11_v3:934,715..938,597(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	expressed	0.54	0.70
Schizont	possibly expressed	0.11	0.93
Gametocyte	expressed	0.50	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.133 | MFS: -3.281 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0924700)

Relative Growth Rate: 0.11 ± 0.10
Confidence: 6.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIC7

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=1.51) with 7S01 (Global RMSD=17.80)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139494

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	35	12	36
disruptive	33	78	44	122
missense	18	55	34	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	65	22	44
disruptive	59	178	84	224
missense	29	129	63	126

PlasmoDB Total SNPs: 128

Non-coding: 63 | Synonymous: 44 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 712 | Molecular Weight (kDa): 84.36

UniProt ID(s): Q8IIC7

PDB ID(s): None

Isoelectric Point: 9.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A