About Gene List

PF3D7_1123700

Genome location: Pf3D7_11_v3:938,756..940,010(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein L37, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005762 mitochondrial large ribosomal subunit
Component GO:0005739 mitochondrion
Function GO:0003735 structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite expressed 0.24 0.84
Schizont possibly expressed 0.03 0.98
Gametocyte expressed 0.25 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1123700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -3.094 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIC6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145389

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 5 6 11
disruptive 1 11 16 24
missense 1 11 16 21

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 17 7 10
disruptive 3 35 26 36
missense 2 33 23 24

PlasmoDB Total SNPs: 90

Non-coding: 86 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 150 | Molecular Weight (kDa): 17.622

UniProt ID(s): Q8IIC6

PDB ID(s): None

Isoelectric Point: 10.49

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013870 Ribosomal protein L37, mitochondrial
PFam PF08561 Ribosomal protein L37, mitochondrial
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31339607 Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. Lacombe A, Maclean AE, ..., Sheiner L 10.1111/mmi.14357
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21