Product Description: 13 kDa ribonucleoprotein-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0031428 | box C/D RNP complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0034511 | U3 snoRNA binding |
| Function | GO:0030621 | U4 snRNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000470 | maturation of LSU-rRNA |
| Process | GO:0030490 | maturation of SSU-rRNA |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.61 | 0.71 |
| Trophozoite | expressed | 0.34 | 0.80 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1123900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: -3.123 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIC4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101116
Most Similar Human Ortholog: A0A3B3IRU2
TM-align score: 0.98 | RMSD: 0.48
Seq Identity: 0.63 | Length: 73 / 145
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100138 | small nuclear ribonucleoprotein 13 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 5 | 11 |
| disruptive | 0 | 0 | 1 | 7 |
| missense | 0 | 0 | 1 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 5 | 9 |
| disruptive | 0 | 5 | 9 | 39 |
| missense | 0 | 3 | 5 | 27 |
PlasmoDB Total SNPs: 117
Non-coding: 107 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 2
Protein Length: 145 | Molecular Weight (kDa): 16.012
UniProt ID(s): Q8IIC4
PDB ID(s): None
Isoelectric Point: 4.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002415 | H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote |
| InterPro | IPR004038 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| InterPro | IPR018492 | Ribosomal protein L7Ae/L8/Nhp2 family |
| InterPro | IPR029064 | 50S ribosomal protein L30e-like |
| PFam | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| Superfamily | SSF55315 | 50S ribosomal protein L30e-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30914254 | The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognizedby the Snu13 core protein in solution | Chagot ME, Quinternet M, ..., Lebars I | 10.1016/j.biochi.2019.03.014 |