Product Description: BEACH domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0012505 | endomembrane system |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.79 | 0.65 |
| Trophozoite | expressed | 1.41 | 0.35 |
| Schizont | expressed | 0.78 | 0.60 |
| Gametocyte | expressed | 0.84 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124100
Resistome Missense Mutations: I1434M, M1441I
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.243 | MFS: -2.721 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIC2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104527
Most Similar Human Ortholog: E5RGU2
TM-align score: 0.88 | RMSD: 1.33
Seq Identity: 0.06 | Length: 54 / 1653
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000035681 | neutral sphingomyelinase activation associated factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 79 | 37 | 83 |
| disruptive | 113 | 187 | 104 | 288 |
| missense | 66 | 143 | 85 | 221 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 36 | 145 | 48 | 101 |
| disruptive | 164 | 394 | 212 | 372 |
| missense | 88 | 294 | 160 | 256 |
PlasmoDB Total SNPs: 240
Non-coding: 58 | Synonymous: 100 | Nonsynonymous: 81 | Stop Codon: 1
Protein Length: 1653 | Molecular Weight (kDa): 195.835
UniProt ID(s): Q8IIC2
PDB ID(s): None
Isoelectric Point: 7.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000409 | BEACH domain |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| InterPro | IPR036372 | BEACH domain superfamily |
| PFam | PF02138 | BEACH domain |
| Superfamily | SSF50729 | WD40-repeat-containing domain superfamily |
| Superfamily | SSF50978 | BEACH domain superfamily |
| Superfamily | SSF81837 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29911335 | A proteomic analysis unravels novel CORVET and HOPS proteins involved inToxoplasma gondii secretory organelles biogenesis. | Morlon-Guyot J, El Hajj H, ..., Daher W | 10.1111/cmi.12870 |