PF3D7_1124200

Genome location: Pf3D7_11_v3:956,931..959,950(-)

Genome classification: Core

Function and Localization

Product Description: thioredoxin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.21	0.88
Schizont	expressed	0.56	0.67
Gametocyte	expressed	0.65	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1124200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.195 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYU5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103779

Most Similar Human Ortholog: F8WB69

TM-align score: 0.39 | RMSD: 3.32

Seq Identity: 0.05 | Length: 42 / 419

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163960	UBX domain protein 7

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	20	10	25
disruptive	12	49	33	49
missense	8	38	28	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	37	19	25
disruptive	25	99	49	95
missense	12	79	43	65

PlasmoDB Total SNPs: 169

Non-coding: 139 | Synonymous: 18 | Nonsynonymous: 11 | Stop Codon: 1

Protein Information

Protein Length: 419 | Molecular Weight (kDa): 49.26

UniProt ID(s): A0A143ZYU5

PDB ID(s): None

Isoelectric Point: 5.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006577	UAS
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF14555	N/A
Superfamily	SSF52833	Thioredoxin-like superfamily