Product Description: bromodomain protein 7
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000792 | heterochromatin |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.36 | 0.82 |
| Trophozoite | expressed | 0.62 | 0.64 |
| Schizont | expressed | 0.25 | 0.83 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.218 | MFS: -2.632 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIC0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 20 | 29 |
| disruptive | 16 | 42 | 36 | 75 |
| missense | 13 | 39 | 34 | 64 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 40 | 20 | 36 |
| disruptive | 28 | 112 | 62 | 149 |
| missense | 20 | 93 | 56 | 94 |
PlasmoDB Total SNPs: 194
Non-coding: 165 | Synonymous: 17 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 525 | Molecular Weight (kDa): 62.334
UniProt ID(s): Q8IIC0
PDB ID(s): None
Isoelectric Point: 4.79
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 35493110 | The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite PlasmodiumFalciparum Cooperates With PfBDP1 in the Silencing of Variant Surface AntigenExpression. | Quinn JE, Jeninga MD, ..., Petter M | 10.3389/fcell.2022.816558 |