Product Description: U6 snRNA-associated Sm-like protein LSm1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Component | GO:0000932 | P-body |
| Component | GO:0005845 | mRNA cap binding complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0000339 | RNA cap binding |
| Process | GO:0016070 | RNA metabolic process |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Process | GO:0006397 | mRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | possibly expressed | 0.10 | 0.94 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.119 | MFS: -3.029 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102846
Most Similar Human Ortholog: E5RH18
TM-align score: 0.73 | RMSD: 1.91
Seq Identity: 0.30 | Length: 40 / 147
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000175324 | LSM1 homolog, mRNA degradation associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 6 | 10 |
| disruptive | 0 | 9 | 4 | 21 |
| missense | 0 | 9 | 4 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 14 | 9 | 10 |
| disruptive | 3 | 27 | 20 | 40 |
| missense | 3 | 21 | 16 | 26 |
PlasmoDB Total SNPs: 70
Non-coding: 65 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 147 | Molecular Weight (kDa): 17.342
UniProt ID(s): Q8IIB9
PDB ID(s): None
Isoelectric Point: 4.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR034104 | Sm-like protein Lsm1 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37746059 | Xrn1 biochemically associates with eisosome proteins after the post diauxic shiftin yeast | Courtin B, Namane A, ..., Fromont-Racine M | 10.17912/micropub.biology.000926 |