Product Description: ethanolamine kinase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.1.82 (Ethanolamine kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0004305 | ethanolamine kinase activity |
| Process | GO:0006629 | lipid metabolic process |
| Process | GO:0006656 | phosphatidylcholine biosynthetic process |
| Process | GO:0006646 | phosphatidylethanolamine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.26 | 0.88 |
| Trophozoite | expressed | 0.54 | 0.69 |
| Schizont | expressed | 0.69 | 0.62 |
| Gametocyte | expressed | 0.29 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.067 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0923700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0923700)
Modification: Disrupted | RMgm-2590
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB7
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.17) with 3FEG (Global RMSD=4.10)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.1.82 | ethanolamine kinase | ATPADPAMPCTPKClEDTAEGTAMgATP2-cholinebetainecysteineInositol... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P35790 | Choline kinase alpha | Homo sapiens | OrthoDB | CHEMBL163319Bis-pyridinium cyclophaneCHEMBL125148CHEMBL332621... |
| Q9Y259 | Choline/ethanolamine kinase | Homo sapiens | OrthoDB | CHEMBL5076272CHEMBL5094399CHEMBL5084844CHEMBL5087533... |
| Q8IM71 | Choline kinase | OrthoDB | Bisquinolinium derivative |
Ortholog Group (OrthoMCL): OG6_101726
Most Similar Human Ortholog: Q5SXX7
TM-align score: 0.85 | RMSD: 2.11
Seq Identity: 0.35 | Length: 139 / 423
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000139163 | ethanolamine kinase 1 |
| ENSG00000143845 | ethanolamine kinase 2 |
Protein Length: 423 | Molecular Weight (kDa): 49.914
UniProt ID(s): Q8IIB7
PDB ID(s): None
Isoelectric Point: 5.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF01633 | N/A |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 205
Non-coding: 191 | Synonymous: 7 | Nonsynonymous: 7 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19845508 | Comparison of the cellular and biochemical properties of Plasmodium falciparumcholine and ethanolamine kinases. | Alberge B, Gannoun-Zaki L, ..., Cerdan R | 10.1042/BJ20091119 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 38410391 | Saccharomyces cerevisiae derived postbiotic alters gut microbiome metabolism inthe human distal colon resulting in immunomodulatory potential in vitro | Duysburgh C, Miclotte L, ..., Marzorati M | 10.3389/fmicb.2024.1358456 |