Product Description: GrpE protein homolog, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0001405 | PAM complex, Tim23 associated import motor |
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0030150 | protein import into mitochondrial matrix |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.27 | 0.87 |
| Trophozoite | expressed | 0.59 | 0.69 |
| Schizont | possibly expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.51 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.922 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0923600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB6
"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=4.44) with 5LLX (Global RMSD=35.27)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100642
Most Similar Human Ortholog: Q9HAV7
TM-align score: 0.73 | RMSD: 2.02
Seq Identity: 0.40 | Length: 172 / 301
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000109519 | GrpE like 1, mitochondrial |
| ENSG00000164284 | GrpE like 2, mitochondrial |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 9 | 19 |
| disruptive | 21 | 42 | 21 | 31 |
| missense | 17 | 28 | 15 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 24 | 9 | 22 |
| disruptive | 38 | 63 | 37 | 77 |
| missense | 22 | 46 | 28 | 45 |
PlasmoDB Total SNPs: 213
Non-coding: 179 | Synonymous: 20 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 301 | Molecular Weight (kDa): 35.043
UniProt ID(s): A9J0F3, C0H5U7, Q8IIB6
PDB ID(s): None
Isoelectric Point: 9.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000740 | GrpE nucleotide exchange factor |
| InterPro | IPR009012 | GrpE nucleotide exchange factor, head |
| InterPro | IPR013805 | GrpE nucleotide exchange factor, coiled-coil |
| PFam | PF01025 | GrpE nucleotide exchange factor |
| Superfamily | SSF51064 | GrpE nucleotide exchange factor, head |
| Superfamily | SSF58014 | GrpE nucleotide exchange factor, coiled-coil |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 28720726 | Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility toFluconazole in Saccharomyces cerevisiae and Candida Species | Demuyser L, Swinnen E, ..., Van Dijck P | 10.1128/mBio.00201-17 |