Product Description: ribosome biogenesis regulatory protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Process | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
| Process | GO:0000055 | ribosomal large subunit export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.50 | 0.40 |
| Trophozoite | expressed | 1.19 | 0.44 |
| Schizont | expressed | 0.24 | 0.87 |
| Gametocyte | expressed | 1.30 | 0.38 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -2.848 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB5
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.82) with 3AM1 (Global RMSD=18.36)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102760
Most Similar Human Ortholog: Q15050
TM-align score: 0.66 | RMSD: 3.41
Seq Identity: 0.23 | Length: 191 / 246
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000179041 | ribosome biogenesis regulator 1 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 16 | 7 | 17 |
| disruptive | 3 | 17 | 10 | 27 |
| missense | 3 | 15 | 9 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 35 | 7 | 16 |
| disruptive | 9 | 54 | 43 | 65 |
| missense | 5 | 42 | 36 | 40 |
PlasmoDB Total SNPs: 123
Non-coding: 111 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 246 | Molecular Weight (kDa): 29.764
UniProt ID(s): Q8IIB5
PDB ID(s): None
Isoelectric Point: 10.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007023 | Ribosomal biogenesis regulatory protein |
| PFam | PF04939 | Ribosomal biogenesis regulatory protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |